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小鼠ig 3-乙酰乌头碱的LD_(50)为3.09mg/kg,其他各种注射途径的LD_(50)在0.40-0.70mg/kg间,约为ig的13-23％;大鼠LD_(50)为小鼠的53-74％。在亚急性毒性实验中,3-乙酰乌头碱中毒剂量可致大鼠呼吸抑制而死亡,家兔除有呼吸抑制外尚出现ECG的异常。组织病理学变化主要为心肌细胞变性,肝细胞轻度损伤。阿托品加人工呼吸对3-乙酰乌头碱所致的大鼠和兔的呼吸抑制有较好的对抗效果。致畸实验未见胎仔畸形。
The LD 50 of ig 3-acetyl aconitine in mice was 3.09 mg / kg, and the LD 50 in other injection routes was about 13-23% of ig in the range of 0.40-0.70 mg / kg. LD_ (50) is 53-74% of mice. In subacute toxicity experiments, 3-acetyl aconitine poisoning can cause respiratory depression and death in rats, rabbits in addition to respiratory depression but there are still ECG abnormalities. Histopathological changes mainly myocardial cell degeneration, mild liver cell damage. Atropine plus artificial respiration on 3-acetyl aconitine induced respiratory depression in rats and rabbits have a better antagonistic effect. Teratogenic test no fetal deformity.