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猪已被认为是异种移植的最理想供体。有关人 猪器官间超急性排斥研究已有所突破 ,而细胞性排斥报道尚少。本文用混合淋巴细胞反应体系研究异种移植细胞性排斥机制 ,发现异种反应明显弱于同种反应 ,而且以直接识别为主 ,这和同种移植细胞性排斥机制一致。抗人CD4单抗和抗猪白细胞抗原SLA DR、DQ单抗都能明显地抑制 (XMLR) ,而抗人CD8单抗无抑制功能 ,表明CD4+T细胞对SLA的识别在异种排斥应答中起重要作用
Pigs have been considered the most ideal donor for xenotransplantation. Research on hyperacute rejection of human pigs has been a breakthrough, and few reports of cellular rejection. In this paper, mixed lymphocyte reaction system to study the mechanism of xenograft cell rejection and found that xeno-reaction was significantly weaker than the same reaction, and direct recognition of the main, which is allograft rejection mechanism consistent. Anti-human CD4 mAb and anti-porcine leukocyte antigen SLA DR, DQ monoclonal antibody were significantly inhibited (XMLR), while anti-human CD8 mAb without inhibition, indicating that CD4 + T cell recognition of SLA in xenotransplantation response Important role