论文部分内容阅读
miRNA是一类高度保守的内源性非编码小RNA,主要作用于靶mRNA的3′-非翻译区,在转录后水平调控基因表达。miRNA可调控造血细胞的增殖、分化及免疫系统的内环境稳定,在固有免疫和适应性免疫中发挥重要的作用。树突状细胞(dendritic cell,DC)是目前发现的抗原递呈能力最强的细胞,是启动、调控并维持免疫应答的中心环节。证据显示,miRNA也参与了树突状细胞的发育、分化和功能的调控,本文将综述miRNA与树突状细胞的关系的最新研究进展。
MiRNAs are a class of highly conserved, endogenous, non-coding small RNAs that act primarily on the 3’-untranslated region of target mRNA and regulate gene expression at post-transcriptional level. MiRNAs regulate the proliferation and differentiation of hematopoietic cells and the internal environment of the immune system, playing an important role in innate immunity and adaptive immunity. Dendritic cells (DCs) are the most frequently found antigen presenting cells and are central to the initiation, regulation and maintenance of immune responses. Evidence shows that miRNAs are also involved in the development, differentiation and function of dendritic cells. In this review, we review recent advances in the relationship between miRNAs and dendritic cells.