报告13例原发性十二指肠腺癌。由于早期本病缺乏特异性症状，确诊时多数较晚。症状常与肿瘤的部位有关，早期症状有上腹部胀痛、呕吐、消化道出血及进行性贫血和黄疸低张十二指肠造影和纤维十二指肠镜检查有助于早期诊断，诊断正确率93％。胰十二指肠切除或姑息性手术是最有效的治疗方法。本组7例行姑息性手术的存活期是3～8个月，6例行胰十二指肠切除术的存活期最短11个月．最长3年。 Reported 13 cases of primary duodenal adenocarcinoma. Due to the lack of specific symptoms in the early stage of the disease, most of the diagnoses were later. Symptoms are often related to the site of the tumor. Early symptoms include upper abdominal pain, vomiting, gastrointestinal bleeding, progressive anemia, and jaundice. Low duodenal angiography and fiber duodenoscopy provide early diagnosis and correct diagnosis. The rate is 93%. Pancreatoduodenectomy or palliative surgery is the most effective treatment. The survival of 7 cases of palliative surgery in this group is 3 to 8 months, 6 cases of pancreaticoduodenectomy survival of the shortest 11 months. Up to 3 years.