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过氧化物酶体增殖物激活受体γ辅助激活因子(PGC)-1基因作为一个细胞核转录因子,在许多基因转录及转录后的剪接修饰中起重要作用,尤其与能量代谢关系密切。 PGC-1富含于肝脏、骨骼肌和棕色脂肪组织,调节糖、脂代谢及线粒体生物合成,并参与脂质分化及适应性产热过程。本文着重对PGC-1调控基因表达的分子机制及其在糖尿病发病中的作用作一综述。
Peroxisome proliferator activated receptor gamma helper factor (PGC) -1 gene, as a nuclear transcription factor, plays an important role in splicing and modification of many genes after transcription and transcription, especially closely related to energy metabolism. PGC-1 is rich in liver, skeletal muscle and brown adipose tissue, regulating sugar, lipid metabolism and mitochondrial biosynthesis, and is involved in lipid differentiation and adaptive thermogenesis. This article focuses on the molecular mechanism of PGC-1 regulation of gene expression and its role in the pathogenesis of diabetes.