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目的:探讨血清同型半胱氨酸联合胱抑素C检测在急性脑梗死治疗前后的临床价值。方法:对134例急性脑梗死患者(观察组)及40例同期健康体检者(对照组)血清同型半胱氨酸与胱抑素C水平进行分析。结果:观察组在治疗前后两种指标明显高于对照组,治疗后明显下降,差异有统计学意义(P<0.05)。应用Spearman相关性分析,对血清胱抑素C与同型半胱氨酸的相关性进行分析,结果 r=0.582,P=0.008。对相关影响因素进行多元线性逐步回归,结果Hcy和Cys-C与收缩压呈正相关,Cys-C与血糖呈正相关,Hcy与血糖无相关性。绘制Hcy与Cys-C的对于急性脑梗死诊断ROC图,Hcy对于急性脑梗死诊断95%可信区间为0.979-0.999,Cys-C对于急性脑梗死诊断95%可信区间0.942-0.987。结论:同型半胱氨酸与胱抑素C对于急性脑梗死有较高的诊断价值,与急性脑梗死的发生与发展均有密切的关系。
Objective: To investigate the clinical value of serum homocysteine combined with cystatin C in the treatment of acute cerebral infarction. Methods: The levels of plasma homocysteine and cystatin C in 134 patients with acute cerebral infarction (observation group) and 40 healthy controls (control group) were analyzed. Results: The two indexes of observation group before and after treatment were obviously higher than that of control group, and obviously decreased after treatment, the difference was statistically significant (P <0.05). Using Spearman correlation analysis, the correlation between serum cystatin C and homocysteine was analyzed. The result was r = 0.582, P = 0.008. Multiple linear regression analysis showed that Hcy and Cys-C were positively correlated with systolic blood pressure, Cys-C was positively correlated with blood glucose, and Hcy was not correlated with blood glucose. ROC maps of Hcy and Cys-C for the diagnosis of acute cerebral infarction were drawn. The 95% confidence interval for Hcy for acute cerebral infarction was 0.979-0.999 and the 95% confidence interval for Cys-C for acute cerebral infarction was 0.942-0.987. Conclusion: Homocysteine and cystatin C have high diagnostic value for acute cerebral infarction, and have close relationship with the occurrence and development of acute cerebral infarction.