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目的观察辛伐他汀治疗不稳定性心绞痛的临床疗效。方法选择72例不稳定性心绞痛患者,随机分为两组,各36例,对照组常规给予硝酸盐、β受体阻滞剂或钙拮抗剂、低分子肝素、血管紧张素转换酶抑制剂;治疗组在常规治疗的基础上加用辛伐他汀20mg,每晚一次,疗程4周,观察用药前后心绞痛发作次数及心电图ST段的改变及硝酸甘油用量,随访6月。结果治疗组心绞痛疗效及心电图改善总有效率优于对照组,两组比较有统计学意义(P<0.05)。结论常规药物治疗辅以辛伐他汀治疗不稳定性心绞痛患者,能有效减少心绞痛发作,改善心肌缺血,并可降低心肌梗死和猝死的发生率,无明显副作用。
Objective To observe the clinical efficacy of simvastatin in the treatment of unstable angina pectoris. Methods Seventy - two patients with unstable angina pectoris were randomly divided into two groups (n = 36). The control group was given routine nitrates, β - blockers or calcium antagonists, low molecular weight heparin and angiotensin converting enzyme inhibitors. The treatment group was given simvastatin 20 mg once a day on the basis of routine treatment for 4 weeks. The number of angina pectoris and ECG ST segment and the amount of nitroglycerin before and after treatment were observed and followed up for 6 months. Results The total effective rate of angina pectoris and electrocardiogram improvement in the treatment group was better than that in the control group, with statistical significance (P <0.05). Conclusion Conventional drug therapy combined with simvastatin in patients with unstable angina pectoris can effectively reduce the incidence of angina pectoris, improve myocardial ischemia, and reduce the incidence of myocardial infarction and sudden death without obvious side effects.