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目的探讨常见的缺血性脑血管狭窄严重程度的影响因素。方法将160例行脑血管造影术检查的缺血性脑血管病患者按血管狭窄严重程度分成轻、中、重度狭窄三组,采用多元Logistic回归进行分析,寻找引起脑动脉狭窄严重程度的影响因素。结果年龄、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)、糖尿病、高血压、同型半胱氨酸(homocysteine,Hcy)水平在不同程度狭窄组中比较差异具有统计学意义(均有P<0.05),其中年龄和LDL-C在重度狭窄组高于中度狭窄和轻度狭窄组(均有P<0.05),Hcy在重度狭窄组高于轻度狭窄组(P<0.05);Logistic回归分析发现年龄(OR=0.061,P<0.001)及高血脂(OR=0.435,P=0.003)是血管狭窄程度的危险因素;相对于糖尿病患者,非糖尿病者是血管狭窄程度的保护因素(OR=-0.821,P=0.009)。结论年龄、高血脂是血管狭窄程度的危险因素,而非糖尿病则是保护因素。
Objective To investigate the influencing factors of the severity of common ischemic cerebrovascular stenosis. Methods 160 patients with ischemic cerebrovascular disease undergoing cerebrovascular angiography were divided into three groups according to the severity of vascular stenosis: light, moderate and severe stenosis. Multivariate Logistic regression analysis was used to find the influencing factors of the severity of cerebral stenosis. . Results There were significant differences in age, low density lipoprotein cholesterol (LDL-C), diabetes mellitus, hypertension, and homocysteine (Hcy) levels in different degree of stenosis group (P <0.05). The age and LDL-C in severe stenosis group were higher than those in moderate stenosis group and mild stenosis group (all P <0.05), while those in severe stenosis group were higher than those in mild stenosis group (P <0.05). Logistic regression analysis showed that age (OR = 0.061, P <0.001) and hyperlipidemia (OR = 0.435, P = 0.003) were risk factors for vascular stenosis. Compared with diabetic patients, non-diabetic patients were the protective factors of the degree of vascular stenosis OR = -0.821, P = 0.009). Conclusion Age and hyperlipidemia are the risk factors for the degree of vascular stenosis, while non-diabetes is the protective factor.