目的探讨孕早期空腹血浆血糖与妊娠期糖代谢异常相关性。方法 150例将要进行孕前体检的孕早期血糖异常患者(血糖异常指数:空腹血糖5.6~7.0 mmol/L)作为临床研究对象,随机分为对照组和治疗组,各75例。治疗组给予孕前饮食及运动指导,孕后持续给予指导。孕早期7~8周内查空腹血糖,孕27~28周进行葡萄糖耐量试验(OGTT),持续指导至分娩;对照组只给予普通的孕前指导及孕期指导,检测血糖同治疗组。研究对比两组患者妊娠期糖尿病发病情况和对新生儿影响。结果两组治疗结果相比较,治疗组患者妊娠期糖尿病发病情况,以及患者血糖对新生儿的影响明显好于对照组,差异有统计学意义(P<0.05)。结论妊娠期糖代谢异常对早期孕妇患者和新生儿有不良影响,应在患者怀孕期间对其进行有效指导治疗,可显著改善患者症状及不良影响,值得在临床中推广运用。 Objective To investigate the relationship between fasting plasma glucose and gestational glucose metabolism in early pregnancy. Methods A total of 150 pregnant women with abnormal blood glucose level (FBG: 5.6-7.0 mmol / L) were enrolled in this study. They were randomly divided into the control group and the treatment group, with 75 cases in each group. The treatment group was given pre-pregnancy diet and exercise guidance, continued to give guidance after pregnancy. Fetal blood glucose was measured within 7 to 8 weeks of pregnancy, and glucose tolerance test (OGTT) was performed 27 to 28 weeks of gestation in the first trimester of pregnancy. The patients in the control group were given only normal pre-pregnancy guidance and pregnancy guidance. Study compared two groups of patients with gestational diabetes incidence and impact on newborns. Results Compared the results of two groups, the incidence of gestational diabetes mellitus in the treatment group and the influence of the patient’s blood glucose on the newborn were significantly better than those in the control group (P <0.05). Conclusion Abnormal glucose metabolism during pregnancy has an adverse effect on early pregnant women and newborns. It should be effectively guided and treated during pregnancy, which can significantly improve the symptoms and adverse effects of patients. It is worth popularizing and applying in clinic.