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目的探讨大剂量奥美拉唑治疗老年上消化道出血患者的临床疗效及其安全性。方法选取2014年8月至2016年10月高州市人民医院收治的70例老年上消化道出血患者作为研究对象,随机将其分为观察组与对照组,各35例。两组患者均给予常规对症支持治疗,同时观察组患者行大剂量奥美拉唑治疗法,对照组患者则行常规剂量奥美拉唑治疗,比较两组患者止血效果、止血时间、不良反应发生情况。结果观察组患者治疗的总有效率为91.4%,显著高于对照组的71.4%,差异有统计学意义(P<0.05);观察组患者的止血时间为(15.4±1.6)h,显著短于对照组的(20.4±2.2)h,差异有统计学意义(P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论采用大剂量奥美拉唑治疗老年性上消化道出血,能有效提高止血效果、缩短止血时间,且不会增加不良反应。
Objective To investigate the clinical efficacy and safety of high-dose omeprazole in elderly patients with upper gastrointestinal bleeding. Methods Seventy patients with upper gastrointestinal bleeding admitted to Gaozhou People’s Hospital from August 2014 to October 2016 were randomly divided into observation group and control group with 35 cases each. Both groups were given conventional symptomatic and supportive treatment. At the same time, patients in observation group were treated with high-dose omeprazole, while those in control group were treated with conventional omeprazole. Hemostatic effect, bleeding time and adverse reactions were compared between the two groups Happening. Results The total effective rate of observation group was 91.4%, which was significantly higher than that of control group (71.4%), the difference was statistically significant (P <0.05); the bleeding time of observation group was (15.4 ± 1.6) h, significantly shorter than (20.4 ± 2.2) h in the control group, the difference was statistically significant (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion Omeprazole treatment of elderly upper gastrointestinal bleeding, can effectively improve the hemostatic effect, shorten the time to stop bleeding, and does not increase the adverse reactions.