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目的:分析短效曲普瑞林不同降调节长方案在体外受精/卵胞浆内单精子注射(IVF/ICSI)中的临床效果。方法:回顾性分析采用长方案降调节行IVF/ICSI治疗的279个周期,根据短效曲普瑞林不同用法分为A、B两组。A组黄体中期开始隔日一次皮下注射曲普瑞林0.1mg,至月经第3天(D3)根据达到降调标准与否分为A1组(达标组)和A2组(未达标组)。A1组D3启用促性腺激素(Gn),A2组曲普瑞林改为0.1mg/d继续皮下注射,直至达到降调标准后启用Gn。B组黄体中期开始每日1次皮下注射曲普瑞林0.1mg,14d后启用Gn。比较3组的治疗效果。结果:3组曲普瑞林用量和天数均有显著统计学差异(P<0.01),A1组Gn天数多于A2、B两组(P<0.05),A1组获卵数多于B组(P<0.05),3组Gn总量、移植数、种植率、临床妊娠率均无统计学差异。结论:3种方案具有相同的临床结局,但隔日1次注射能减少曲普瑞林的用量,节约部分药费。
OBJECTIVE: To analyze the clinical effect of short-acting triptorelin with different down-regulation regimens in in vitro fertilization / intracytoplasmic sperm injection (IVF / ICSI). Methods: A retrospective analysis of 279 long cycles of regimen IVF / ICSI regimen was divided into A and B groups according to the different usage of short-acting triptorelin. A group of mid luteal starting next day subcutaneous injection of triptorelin 0.1mg, to the first three days of menstruation (D3) according to the criteria to be lowered into A1 group (standard group) and A2 group (non-compliance group). Gd was activated in group A1, triptorelin in group A2 was changed to 0.1 mg / d, and subcutaneous injection was continued until Gn was reached after the reduction was reached. B group corpus luteum started once daily subcutaneous injection of triptorelin 0.1mg, Gd after 14d. Compare the treatment effect of 3 groups. Results: The amount of triptorelin and the number of days in three groups were significantly different (P <0.01). The number of Gn days in A1 group was more than that in A2 and B groups (P <0.05) <0.05). There was no significant difference in the total amount of Gn, the number of implants, the implantation rate and the clinical pregnancy rate among the three groups. CONCLUSIONS: The three regimens have the same clinical outcome, but one injection every other day can reduce the amount of triptorelin used and save some of the cost.