目的　观察枢丹的止吐疗效和毒性。方法　对 2 0例接受大剂量顺铂化疗的患者 ,采用随机自身对照的方法 ,比较枢丹与胃复安的疗效和毒性。结果　枢丹能有效预防顺铂所致的恶心、呕吐 ,其止吐疗效优于胃复安 ,两药的止吐有效率分别为 70 %和 30 % ,完全缓解率分别为 5 5 %和 10 % ,两药的疗效统计学差异明显。结论　枢丹为肿瘤化疗安全、有效的止吐药。 Objective To observe the antiemetic efficacy and toxicity of Shudan. Methods Twenty patients who received high-dose chemotherapy with cisplatin were randomized and compared with the efficacy and toxicity of metoclopramide. Results Shudan can effectively prevent nausea and vomiting caused by cisplatin. Its antiemetic efficacy is better than metoclopramide. The antiemetic efficacy of the two drugs is 70% and 30% respectively, and the complete remission rate is 55% and 10% respectively. %, the statistical difference in the efficacy of the two drugs was significant. Conclusion Shudan is a safe and effective antiemetic drug for cancer chemotherapy.