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目的:研究右归丸联合液体钙片对老年骨质疏松症患者血清雌激素水平、骨钙素(BGP)水平及临床疗效的影响。方法:选取2014年10月至2015年9月本院收治的82例老年骨质疏松症患者,根据入院顺序分为观察组和对照组,每组41例。对照组使用骨化三醇软胶囊和液体钙软胶囊进行治疗,观察组在此基础上加以右归丸进行治疗。比较两组患者治疗前和治疗1个月后血清雌二醇(E2)水平、BGP水平、骨密度变化,分析两组患者的临床疗效。结果:治疗后,观察组的血清E2水平显著高于对照组(P<0.05),BGP水平显著低于对照组(P<0.05),腰椎L1-4正位、右侧股骨颈、左侧股骨颈骨密度显著高于对照组(p<0.05),总临床疗效率显著高于对照组(P<0.05)。结论:右归丸联合液体钙片治疗老年骨质疏松症患者能明显改善患者血清雌激素、BGP水平,增加骨密度,临床疗效良好。
Objective: To study the effects of Yougui Pills combined with liquid calcium on serum estrogen level, osteocalcin (BGP) level and clinical efficacy in elderly patients with osteoporosis. Methods: A total of 82 elderly osteoporosis patients admitted to our hospital from October 2014 to September 2015 were selected and divided into observation group and control group according to admission sequence, with 41 cases in each group. The control group was treated with calcitriol soft capsule and liquid calcium soft capsule. The observation group was treated with Yougui Wan on this basis. The levels of serum estradiol (E2), BGP level and bone mineral density in two groups before treatment and one month after treatment were compared. The clinical efficacy of the two groups was analyzed. Results: After treatment, the level of serum E2 in the observation group was significantly higher than that in the control group (P <0.05), and the level of BGP in the observation group was significantly lower than that in the control group (P <0.05) The cervical density was significantly higher than that of the control group (p <0.05), and the total clinical response rate was significantly higher than that of the control group (P <0.05). Conclusion: Yougui pills combined with liquid calcium in elderly patients with osteoporosis can significantly improve serum estrogen and BGP levels, increase bone mineral density, good clinical efficacy.