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目的探讨妊娠高血压综合征(妊高症)妇女凝血功能及D-二聚体检测的临床意义。方法 160例妊娠妇女(妊娠组),根据妊娠情况分为正常妊娠组和妊高症组,各80例。并选择同期在本院体检的非妊娠妇女80例作为对照组。对各组均进行凝血功能及D-二聚体检测,比较检测指标的差异。结果经比较,妊娠组的凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)均显著低于对照组(P<0.05),纤维蛋白原(FIB)以及D-二聚体值则显著高于对照组(P<0.05);妊娠组中妊高症组的PT(7.63±0.64)、APTT(18.52±2.77)、TT(12.49±0.41)s值均显著低于正常妊娠组的PT(9.21±0.84)、APTT(24.86±3.15)、TT(14.62±0.44)s(P<0.05),FIB(4.68±0.92)g/L、D-二聚体(568.55±144.23)μg/L值则显著高于正常妊娠组的(3.47±0.66)g/L、(324.53±75.66)μg/L(P<0.05)。结论通过对妊高症妇女的凝血功能及D-二聚体进行检测,可以动态观察其凝血功能、纤溶功能的变化特征,对于病情监测、诊治等均有重要意义,值得在临床进一步推广。
Objective To investigate the clinical significance of coagulation function and D-dimer in women with pregnancy-induced hypertension (PIH). Methods One hundred and sixty pregnant women (pregnancy group) were divided into normal pregnancy group and pregnancy-induced hypertension group according to their pregnancy status, 80 cases each. And select the same period in our hospital physical examination of 80 non-pregnant women as a control group. Blood coagulation and D-dimer were detected in each group, and the differences of detection indexes were compared. Results Compared with the control group (P <0.05), fibrinogen (FIB) and fibrinogen (FIB), the prothrombin time (PT), active partial thromboplastin time (APTT) and thrombin time (TT) D-dimer was significantly higher than that of the control group (P <0.05). PT, (7.63 ± 0.64), APTT (18.52 ± 2.77) and TT (12.49 ± 0.41) s were significantly higher in the pregnancy- (P <0.05), FIB (4.68 ± 0.92) g / L, D-dimer (568.55) in PTB group were lower than those in normal pregnancy group (9.21 ± 0.84, APTT 24.86 ± 3.15, TT 14.62 ± 0.44, ± 144.23 μg / L was significantly higher than that of normal pregnancy group (3.47 ± 0.66 g / L, (324.53 ± 75.66) μg / L, P <0.05). Conclusions The coagulation function and D-dimer in pregnant women with PIH can be dynamically observed in coagulation function and fibrinolytic function, which is important for disease monitoring, diagnosis and treatment, which is worth further promotion in clinic.