【摘 要】
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Cancer cell motility and its heterogeneity play an important role in metastasis,which is responsible for death of 90％ of cancer patients.Here,in combination with
【机 构】
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Chongqing Key Laboratory of Soft Condensed Matter Physics and Smart Materials, College of Physics, C
论文部分内容阅读
Cancer cell motility and its heterogeneity play an important role in metastasis,which is responsible for death of 90％ of cancer patients.Here,in combination with a microfluidic technique,single-cell tracking,and systematic motility analysis,we present a rapid and quantitative approach to judge the motility heterogeneity of breast cancer cells MDA-MB-231 and MCF-7 in a well-defined three-dimensional (3D) microenvironment with controllable conditions.Following this approach,identification of highly mobile active cells in a medium with epithelial growth factor will provide a practical tool for cell invasion and metastasis investigation of multiple cancer cell types,including primary cells.Further,this approach could potentially become a speedy (～ hours) and efficient tool for basic and clinical diagnosis.
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