二恶英类化合物具有致癌、致畸作用以及心血管神经内分泌毒性。2,3,7,8_四氯二苯并对二恶英(TCDD)是二恶英类化合物中毒性最强的一种。本文以二恶英_芳香烃受体为主线,从TCDD诱导斑马鱼胚胎下颌发育短小、神经元缺失、抑制总主静脉退化、抑制红细胞生成、心脏形态和功能缺陷、血液循环障碍、水肿、致死等方面概述了TCDD对斑马鱼胚胎发育毒性机制的研究现状。 Dioxin-like compounds have carcinogenic, teratogenic effects and cardiovascular neuroendocrine toxicity. 2,3,7,8_ Tetrachlorodibenzo-p-dioxins (TCDDs) are the most toxic of dioxin-like compounds. In this paper, dioxin _ aromatic hydrocarbon receptor as the main line, from the TCDD induced zebrafish embryo short mandibular development, neuronal loss, inhibition of total venous degeneration, inhibition of erythropoiesis, cardiac morphology and function defects, blood circulation disorders, edema, lethal And other aspects of the TCDD on zebrafish embryonic development of toxicological research.