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目的观察肺结核患者氧化/抗氧化失衡的特点及相关影响因素。方法用比色法对20例正常对照者和120例肺结核患者血清的超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GPX)、丙二醛(MDA)进行检测。结果与正常对照组相比,肺结核患者血清SOD、GPX活性降低,MDA含量增加(P<0.01)。具有浸润、空洞、纤维化和/或毁损肺等多种影像学改变的肺结核患者以及红细胞沉降率增加的患者SOD、GPX进一步降低(P<0.01),但MDA无显著性变化。卡方检验及logistic回归分析显示,影像学多种病变并存和红细胞沉降速度增快分别与SOD和GPX的降低密切相关(P<0.01)。结论肺结核患者存在着氧化/抗氧化失衡,影像学多种病变并存和红细胞沉降速度增快分别与SOD和GPX的降低密切相关。
Objective To observe the characteristics of oxidative / antioxidant imbalance in pulmonary tuberculosis patients and the related influential factors. Methods The serum levels of superoxide dismutase (SOD), glutathione peroxidase (GPX) and malondialdehyde (MDA) in 20 normal controls and 120 pulmonary tuberculosis patients were detected by colorimetric assay. Results Compared with the normal control group, the activity of SOD and GPX in the patients with pulmonary tuberculosis decreased and the content of MDA increased (P <0.01). Patients with pulmonary tuberculosis with multiple imaging changes such as infiltration, voids, fibrosis and / or destroying lung, and patients with increased erythrocyte sedimentation rate also had lower SOD and GPX (P <0.01) but no significant changes in MDA. Chi-square test and logistic regression analysis showed that coexistence of multiple lesions and rapid erythrocyte sedimentation rate were closely related to the decrease of SOD and GPX (P <0.01). Conclusions Oxidation / antioxidant imbalance exists in patients with pulmonary tuberculosis. The coexistence of multiple lesions in imaging and the rapid erythrocyte sedimentation rate are closely related to the decrease of SOD and GPX, respectively.