Rho蛋白作为信号分子,联系细胞表面受体和肌动蛋白细胞骨架的组建,在细胞代谢进程中起重要作用。在动脉血管中,Rho信号途径参与调节平滑肌细胞收缩、迁移、增殖、分化,内皮功能改变,巨噬细胞功能改变,血栓形成,氧化应激与细胞外基质合成等多种动脉粥样硬化的病理生理过程。 Rho protein, as a signaling molecule, plays an important role in the process of cellular metabolism in connection with the formation of cell surface receptors and actin cytoskeleton. In arterial vessels, the Rho signaling pathway is involved in the pathogenesis of a variety of atherosclerotic diseases that regulate smooth muscle cell contraction, migration, proliferation, differentiation, endothelial function, changes in macrophage function, thrombosis, oxidative stress and extracellular matrix synthesis Physiological process.