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用大鼠4动脉阻断全脑缺血模型和大鼠纹状体灌流方法,观察到大鼠急性全脑缺血20min,纹状体细胞外液谷氨酸、牛磺酸、γ-氨基丁酸及多巴胺含量显著升高。丁基苯酞40mg·kg-1能使全脑缺血20min纹状体细胞外液多巴胺及其代谢产物DOPAC含量明显降低,并能降低缺血前后纹状体细胞外液甘氨酸含量,而对谷氨酸等其他氨基酸无显著影响。结果提示丁基苯酞对缺血性脑损伤可能有保护作用。
The rat model of global cerebral ischemia and rat striatum perfusion were blocked by rat 4 arteries and the levels of glutamate, taurine and γ-aminobutyric acid in striatum were observed after 20 min acute global cerebral ischemia Acid and dopamine levels were significantly higher. Butylphthalide 40 mg · kg-1 can significantly reduce dopamine and its metabolite DOPAC in striatum 20 min after global cerebral ischemia and decrease the content of extracellular glycine in striatum before and after ischemia, Other amino acids such as amino acid had no significant effect. The results suggest that butylphthalide may have a protective effect on ischemic brain injury.