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复制犬失血性休克模型。动物随机分为两组：失血对照组（ｎ＝５），失血＋异搏定组（ｎ＝６）。结果发现，异搏定治疗后肾脏组织内黄嘌呤氧化酶活性和丙二醛含量均较失血对照组明显降低，而锰－超氧化物歧化酶活性却显著高于失血对照组，肾脏组织电镜观察显示其超微结构损伤也较失血对照组轻。提示钙拮抗剂异搏定治疗失血性休克可以减轻肾脏损伤，其机理与改善内脏灌流，减少氧自由基生成有关。
Copy dog hemorrhagic shock model. Animals were randomly divided into two groups: blood loss control group (n = 5), blood loss + verapamil group (n = 6). The results showed that xanthine oxidase activity and malondialdehyde content in the kidney tissue were significantly decreased after treatment with verapamil compared with the control group, but the activity of manganese-superoxide dismutase was significantly higher than that in the control group and the electron microscope The ultrastructural damage was also lighter than the control group. Prompt calcium antagonist verapamil treatment of hemorrhagic shock can reduce renal damage, its mechanism and improve visceral perfusion and reduce the generation of oxygen free radicals.