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目的分析肾移植患者术后肺曲霉菌感染的不同CT表现特点,为合理选用抗菌药物治疗肺曲霉菌病提供依据。方法选取2011年1月-2013年12月进行肾移植手术后肺曲霉菌感染的42例患者为研究对象,随机分为两组,每组各21例,观察并分析两组患者的不同CT表现,对照组患者采用常规抗真菌感染治疗措施,试验组患者采用伏立康唑治疗,分别观察两组肾移植术后肺曲霉菌病患者的临床疗效进行统计分析。结果治疗前CT结果表现为结节、空气新月征、晕症分布率,对照组患者分别为80.95%、42.86%、33.33%,试验组分别为76.19%、52.38%、33.33%,两组患者的CT特征相同,主要以结节、空气新月征为主;治疗后对照组患者曲霉菌属感染半乳甘露聚糖阴性占66.67%、阳性占33.33%,试验组患者曲霉菌属感染半乳甘露聚糖阴性占90.48%、阳性占9.52%,两组比较差异有统计学意义(P<0.05);治疗后总有效率对照组为85.71%、试验组为95.23%,试验组总有效率明显高于对照组,差异有统计学意义(P<0.05)。结论肾移植术后肺曲霉菌病患者的CT表现主要以结节、空气新月征和晕症等;使用伏立康唑抗真菌药物治疗肾移植术后肺曲霉菌病疗效确切,有效提高患者的治疗有效率。
Objective To analyze the CT manifestations of pulmonary aspergillosis in renal transplant recipients and provide evidence for rational use of antibacterials in the treatment of pulmonary aspergillosis. Methods Forty-two patients with pulmonary aspergillosis after renal transplantation from January 2011 to December 2013 were selected and randomly divided into two groups with 21 cases in each group. The CT findings of the two groups were observed and analyzed. , The control group of patients with conventional anti-fungal infection treatment, the experimental group were treated with voriconazole, were observed after the two groups of patients with pulmonary aspergillosis clinical efficacy of statistical analysis. Results Before treatment, the results of CT showed nodules, air crescent sign, and the distribution rate of fainting, which were respectively 80.95%, 42.86% and 33.33% in the control group, 76.19%, 52.38% and 33.33% in the experimental group, respectively CT features of the same, mainly nodules, air crescent sign; control group patients with Aspergillus infection of galactomannan negative accounted for 66.67%, positive accounted for 33.33%, the test group of patients with Aspergillus infections galactose Mannan negative accounted for 90.48%, positive accounted for 9.52%, the difference between the two groups was statistically significant (P <0.05); after treatment, the total effective rate was 85.71% in the control group, the experimental group was 95.23%, the total effective rate was significantly Higher than the control group, the difference was statistically significant (P <0.05). Conclusion CT manifestations of patients with pulmonary aspergillosis after kidney transplantation are mainly nodules, air crescent syndrome and fainting, etc. The use of voriconazole antifungal agents to treat pulmonary aspergillosis after renal transplantation is effective and effective in improving the treatment of patients with pulmonary aspergillosis effectiveness.