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目的:讨论P~（53）、C-erbB-2与大肠癌发生的关系及其在大肠癌早期诊断中的价值。方法:用免疫组化(S-P)法染色观察大肠癌101例、腺瘤性息肉54例及炎性息肉46例P~（53）、C-erbB-2的表达情况。结果:P~（53）、C-erbB-2在腺癌中有很高的阳性表达率(48/101、55/101)与良性病变比较有非常显著的差异(P<0.01);在腺瘤性息肉中二者的阳性率(7/54、14/54)也明显高于炎性息肉(P<0.05)。结论:p~(53)、C-erbB-2参与大肠癌的发生,二者在粘膜上皮中呈阳性表达对早期诊断粘膜上皮癌变有重要的参考价值。
Objective: To discuss the relationship between P53 and C-erbB-2 and colorectal cancer and its value in early diagnosis of colorectal cancer. Methods: Immunohistochemistry (S-P) staining was used to observe the expression of P53 and C-erbB-2 in 101 cases of colorectal cancer, 54 cases of adenomatous polyps, and 46 cases of inflammatory polyps. Results: The positive rate of P53 and C-erbB-2 was significantly higher in adenocarcinoma (48/101, 55/101) than in benign lesions (P<0.01); The positive rates of both of the tumor polyps (7/54, 14/54) were also significantly higher than those of inflammatory polyps (P<0.05). Conclusion: p53 and C-erbB-2 are involved in the development of colorectal carcinoma. The positive expression of both of them in mucosal epithelium is of great value in the early diagnosis of epithelial carcinogenesis.