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目的比较冠心病患者和健康人血清中胎盘生长因子(PIGF)水平,探讨其与冠心病、冠脉病变程度、心肌损伤的相关性。方法采用ELISA法测定87例冠心病患者(冠心病组)及61例健康人(对照组)血清的PIGF水平,分析血清PIGF水平与冠心病的相关性;将冠状动脉造影结果与血清PIGF水平进行比较,分析血清PIGF水平与冠心病患者冠脉病变支数及Gensini冠脉病变积分之间的相关性;以cTnI0.03ng/ml和0.1ng/ml为分界值,将冠心病组分成冠心病Ⅰ组、Ⅱ组和Ⅲ组,比较各组之间血清PIGF水平。结果冠心病组血清PIGF水平为(11.55±3.10)ng/ml,高于对照组的(5.81±2.21)ng/ml,差异有统计学意义(P<0.05)。血清PIGF水平与冠脉病变支数和Gensini冠脉病变积分均无相关性(P>0.05)。冠心病Ⅱ组和冠心病Ⅲ组血清PIGF水平分别为(13.12±2.45)、(14.62±3.25)ng/ml,与冠心病Ⅰ组的(9.10±2.31)ng/ml比较,差异均有统计学意义(P<0.05)。结论血清PIGF水平与冠心病、心肌受损之间存在相关性,PIGF水平与冠脉梗塞的严重程度的相关性需进一步研究。
Objective To compare the serum levels of placental growth factor (PIGF) in patients with coronary heart disease and healthy people and to explore their correlation with coronary heart disease, coronary artery disease and myocardial injury. Methods Serum levels of PIGF in 87 patients with coronary heart disease (CHD) and 61 healthy people (control group) were measured by ELISA. The correlation between serum PIGF level and coronary heart disease was analyzed. The results of coronary angiography and serum PIGF The correlation between serum PIGF level and coronary artery lesion count and Gensini coronary artery disease score was analyzed. The coronary heart disease group was divided into coronary heart disease Ⅰ (cTnI0.03ng / ml and 0.1ng / ml) Group, group Ⅱ and group Ⅲ. The level of serum PIGF was compared between groups. Results The serum PIGF level in CHD group was (11.55 ± 3.10) ng / ml, which was significantly higher than that in the control group (5.81 ± 2.21) ng / ml (P <0.05). There was no correlation between serum PIGF level and the number of coronary lesions and Gensini coronary lesions (P> 0.05). The serum PIGF levels in CHD Ⅱ and CHD Ⅲ groups were (13.12 ± 2.45) and (14.62 ± 3.25) ng / ml, respectively, which were significantly different from those in CHD group Ⅰ (9.10 ± 2.31) ng / ml Significance (P <0.05). Conclusion There is a correlation between serum PIGF level and coronary heart disease and myocardial damage. The correlation between PIGF level and the severity of coronary artery infarction needs further study.