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目的:研究血清丙氨酸氨基转移酶(ALT)与天门冬氨酸氨基转移酶(AST)比值与男性乳腺癌发病率的关系。方法:对15例男性乳腺癌患者和34例对照者进行血清丙氨酸氨基转移酶和天门冬氨酸氨基转移酶实验室检查,将两者进行统计学比较分析。结果:乳腺癌患者的ALT和AST水平均高于良性乳腺病患者,其两者比值(AST/ALT)与良性患者相比也偏高。结论:肝损伤导致体内雌激素水平增高是男性乳腺癌发病的重要因素之一。
Objective: To study the relationship between serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and the incidence of male breast cancer. Methods: Serum alanine aminotransferase and aspartate aminotransferase were detected in 15 cases of male breast cancer patients and 34 cases of controls. The two groups were compared statistically. Results: The levels of ALT and AST in patients with breast cancer were higher than those in patients with benign breast disease. The ratio of AST / ALT was also higher in patients with benign breast disease. Conclusion: Liver injury leads to the increase of estrogen level in the body is one of the important factors in the pathogenesis of male breast cancer.