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过氧化物酶体增殖物激活受体(PPAR)是配体激活的核转录因子,在糖脂代谢中发挥重要作用,这在一定程度上改善糖尿病血脂异常和胰岛素抵抗,减少心血管并发症发生的危险因素。同时,动物模型的数据显示,PPAR的激活也有独立的抗动脉粥样硬化作用,包括抑制血管炎症,氧化应激和激活肾素-血管紧张素系统等。这使PPAR成为研究治疗糖尿病及其心血管并发症理想的靶基因。
Peroxisome proliferator-activated receptor (PPAR) is a ligand-activated nuclear transcription factor that plays an important role in the metabolism of glycolipids, which to some extent ameliorates diabetic dyslipidemia and insulin resistance and reduces the incidence of cardiovascular complications Risk factors. Meanwhile, data from animal models show that PPAR activation also has independent anti-atherosclerotic effects, including inhibition of vascular inflammation, oxidative stress and activation of the renin-angiotensin system. This makes PPAR an ideal target for studying the treatment of diabetes and its cardiovascular complications.