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目的探讨帕罗西汀对脑卒中后抑郁(PSD)及神经功能恢复的影响。方法 88例PSD患者随机分为帕罗西汀治疗组(43例)和对照组(45例)。治疗组在对照组常规治疗的基础上加用帕罗西汀10mg/d×7d,20mg/d×23d。比较两组临床疗效、治疗前后神经功能缺损程度评分及汉密尔顿抑郁量表(HAMD)评分。结果治疗组显效率高于对照组(60.47%vs.37.78%)(P<0.05)。治疗后两组神经功能缺损程度评分和HAMD评分均较治疗前明显改善(P<0.01),治疗组神经功能缺损程度评分和HAMD评分均低于对照组(P<0.05)。结论帕罗西汀可改善PSD患者的抑郁情绪,促进神经功能恢复。
Objective To investigate the effect of paroxetine on post-stroke depression (PSD) and neurological function recovery. Methods 88 patients with PSD were randomly divided into paroxetine treatment group (43 cases) and control group (45 cases). The treatment group was treated with paroxetine 10mg / d × 7d, 20mg / d × 23d on the basis of conventional treatment in the control group. The clinical curative effect, the score of neurological deficit before and after treatment and the Hamilton Depression Rating Scale (HAMD) were compared. Results The effective rate of treatment group was higher than that of control group (60.47% vs.37.78%) (P <0.05). After treatment, the scores of neurological deficits and HAMD scores in both groups were significantly improved (P <0.01). The scores of neurological deficits and HAMD scores in the treatment group were lower than those in the control group (P <0.05). Conclusion Paroxetine can improve the depression of PSD patients and promote the recovery of neurological function.