矽尘可以引起肺的纤维化已成定论,虽然其产生的机理尚未完全阐明,但人们已公认肺泡巨噬细胞(PAM)与成纤维细胞之间的相互作用是矽肺纤维化产生的关键。本文旨在试述PAM在矽肺纤维化过程中是如何对肺成纤维细胞进行调节的。 一、矽肺纤维化 尽管国内外学者对矽肺纤维化的发病机理作了大量的研究工作。提出了不少假设和观 Silica dust can cause pulmonary fibrosis has been a definite conclusion, although the mechanism of its production has not yet been fully elucidated, but it is recognized that the interaction between alveolar macrophages (PAM) and fibroblasts is the key to the development of silicosis. This article aims to describe how PAM modulates lung fibroblasts during silicotic fibrosis. First, silicosis Although the domestic and foreign scholars on the pathogenesis of silicosis made a lot of research work. Put forward many assumptions and concepts