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目的:观察调肝解毒方对激怒应激模型大鼠胃肠运动变化的干预作用。方法:75只模型SD大鼠随机分为5组,除正常对照组外,其余4组采用长海绵钳夹尾、捆绑及捆绑后合笼的综合方法制造大鼠肝胃不和证模型。自造模第7天起药物干预治疗,检测记录大鼠体质量、食量、甘味嗜好比、旷场行为、小肠推进率等指标。结果:与正常对照组比较,模型组体质量、食量、甘味嗜好比、小肠推进率、旷场活动性显著降低,拒俘反应性显著增高。与模型组比较,柴胡疏肝组在造模14 d及调肝解毒方低、高剂量组在第7、14 d体质量、食量有所好转;调肝解毒方低、高剂量组在第7、14 d甘味嗜好比有所好转(P<0.05或P<0.01);柴胡疏肝组及调肝解毒方低、高剂量组旷场活动性、拒俘反应性、胃肠推进率均有好转(P<0.05或P<0.01)。结论:调肝解毒方药对胃肠功能具有一定的改善作用。
Objective: To observe the intervention effect of Tiaogan Jiedu Fang on gastrointestinal motility in rats with irritable stress. Methods: Seventy-five SD rats were randomly divided into five groups. Except the normal control group, the other four groups were treated with long sponge wrench, tail bundled and bundled tail bundles. From the 7th day after model intervention, the body weight, appetite, sweet taste ratio, open field behavior and small intestine propulsion rate were recorded and recorded. Results: Compared with the normal control group, the body mass, food intake, sweet taste ratio, small intestine propulsion rate, open field activity significantly decreased, and the reactivity of captive trap increased significantly. Compared with the model group, Chaihu Shugan group was lower on the 14th day after modeling and Tiaogan detoxification, while the body weight and appetite of the high dose group were improved on the 7th and 14th day. In the low and high dose Tiaogan detoxification group, (P <0.05 or P <0.01). The open mobility, rejection reaction and gastrointestinal propulsion rate of Chaihu Shugan group and Tiaogan detoxification group in both low and high dose groups were significantly higher than those of control group There was improvement (P <0.05 or P <0.01). Conclusion: Tonic Liver detoxification recipe on gastrointestinal function has a certain effect of improvement.