ｒａｓ基因是一个相当保守的管家基因，其编码蛋白Ｐ２１ｒａｓ负有重要的信号传导功能。本文拟对ＴＣＲ信号途径、共刺激信号途径以及ＩＬ２Ｒ信号途径同Ｐ２１ｒａｓ活化之间关系方面的研究进展进行综述，并认为作为Ｔ淋巴细胞内信号转导网络的一个中心枢纽，Ｐ２１ｒａｓ在Ｔ淋巴细胞接受外界信号刺激而增殖活化过程中具有极其重要的信号转导作用 The ras gene is a rather conserved housekeeping gene that encodes the protein P21ras, which plays an important signaling role. This article intends to review the progress of TCR signaling pathway, co-stimulatory signaling pathway and the relationship between IL-2R signaling pathway and P21ras activation, and as a central hub of T lymphocyte signaling network, P21ras in T lymphocytes Cells receive the external signal stimulation and proliferation activation has an extremely important signal transduction