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人工培植牛黄生产中,胆囊内接种大肠杆菌是关系到牛黄产量的关键问题之一。为了探讨接种大肠杆菌后胆汁理化性质的变化规律,我们在体外37℃条件下研究了大肠杆菌对牛胆汁理化特性的影响,并观测了所得胆汁沉淀物的急性毒性及其对家兔的降压作用。材料和方法一、实验动物瑞士种小白鼠,雌雄各半,体重15～19克,由山东省中医药研究所提供;哈白兔,雌雄均用,体重1.5～2.0公斤,由山东农业大学实验动物场提供。
Artificial cultivation of bezoar production, the gallbladder inoculation of E. coli is one of the key issues related to the yield of bezoar. In order to explore the changes of physical and chemical properties of bile after inoculation with E. coli, we studied the effect of Escherichia coli on the physicochemical properties of bovine bovine in vitro at 37 ℃, and observed the acute toxicity of bile precipitate and its antihypertensive effect on rabbits effect. Materials and methods First, the experimental animals Swiss species of mice, male and female, weighing 15-19 grams, provided by the Shandong Institute of Traditional Chinese Medicine; halau rabbits, both male and female, weighing 1.5 to 2.0 kg, Shandong Agricultural University experiment Animal field available.