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目的 :探讨 2型糖尿病患者的血管性假血友病因子 (VWF)、血小板α颗粒膜蛋白 - 140 (GMP -140 )、可溶性纤维蛋白单体复合物 (SFMC)等 3项血栓分子标志物的临床意义。方法 :采用ELISA法测定 6 0例2型糖尿病患者血清VWF ,GMP - 140和SFMC含量 ,并与 30例健康人比较。结果 :2型糖尿病组VWF ,GMP -140 ,SFMC均较健康人组高 (P <0 0 1) ,其中有合并症比无合并症组亦明显增高 (P <0 0 1)。结论 :2型糖尿病患者处于高凝状态 ,与多种因素有关 ,3项血栓分子标志物是 2型糖尿病患者血管病变的危险因子
Objective: To investigate the clinical significance of three thrombus molecular markers such as VWF, GMP-140 (GMP-140) and soluble fibrin monomer complex (SFMC) Clinical significance. Methods: The serum levels of VWF, GMP - 140 and SFMC in 60 patients with type 2 diabetes mellitus were determined by ELISA and compared with 30 healthy people. Results: The levels of VWF, GMP-140 and SFMC in type 2 diabetic patients were significantly higher than those in healthy controls (P <0.01), and those with complications were significantly higher than those without complications (P <0.01). Conclusion: Patients with type 2 diabetes mellitus are hypercoagulable and are related to various factors. Three thrombotic markers are risk factors for vascular disease in type 2 diabetic patients