目的 :观察格拉诺赛特 (GranocyterhG CSF)高低剂量预防化疗引起白细胞减少的观察效果。方法 :用药参照原来白细胞下降的程度 ,在化疗后 48小时先给予格拉诺赛特 ,待白细胞正常用量减半 ,停药设对照周期观察。30例消化系癌在第一周期化疗后 ,白细胞 <4.0× 10 9/L时 ,对照给格拉诺赛特治疗用药升白 ,作为对照周期。于第二周期化疗结束后 48小时预防给药 ,每日皮下注射格拉诺赛特 10 0 μg ,用 3～ 5日后 ,当白细胞升至 >10 .0× 10 9/L ,剂量减半 ,再用 5～ 7日 ,总用药 10日。结果 :30例中 ,男性 13例 ,女性 17例。食管癌 1例 ,胃癌 12例 ,肠癌 9例 ,肝癌 3例 ,胰腺癌 5例。全部 30例 ,总有效率 10 0 % (有效率 10 0 % ,无效率 0 )。全组只有 1例用药第 2天出现不良作用。结论 :参照对第一周期化疗的患者白细胞下降程度 ,于第二周期化疗结束后 48小时用高低剂量的格拉诺赛特 ,可有效防止白细胞下降 ,升白疗效好 ,效果稳定 Objective: To observe the effect of GranocyterhG CSF in preventing leukopenia caused by chemotherapy. Methods: Medication according to the original degree of leukopenia, 48 hours after chemotherapy to give Granosause, to be half the normal dosage of leukocytes, stopping the control cycle of observation. 30 cases of digestive cancer in the first cycle after chemotherapy, white blood cells <4.0 × 10 9 / L, the control to the treatment of granuloside treatment white, as the control cycle. 48 hours after the end of the second cycle of chemotherapy to prevent the administration of daily subcutaneous injection of granisetron 10 0 μg with 3 to 5 days, when the white blood cells rose to> 10 .0 × 10 9 / L, the dose by half With 5 to 7 days, the total medication on the 10th. Results: Among 30 cases, 13 were male and 17 were female. 1 case of esophageal cancer, 12 cases of gastric cancer, 9 cases of intestinal cancer, 3 cases of liver cancer and 5 cases of pancreatic cancer. All 30 cases, the total effective rate 100% (effective rate 100%, ineffective rate 0). Only one patient in the whole group had adverse effects on the second day. Conclusion: According to the degree of leukopenia in patients receiving chemotherapy in the first cycle, high and low doses of granolase 48 hours after the end of the second cycle chemotherapy can effectively prevent leukopenia, and the effect of lightening is good and the effect is stable