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目的 :探讨新型抗酸剂氢氧镁铝对实验性胃溃疡的影响。方法 :利用小鼠应激性胃溃疡、小鼠烧灼性胃溃疡、大鼠利血平性胃溃疡及大鼠幽门结扎性胃溃疡的模型 ,同时在幽门结扎性胃溃疡模型中观察其对胃液量、胃酸酸度、胃液 p H值及胃蛋白酶活性的影响。结果 :氢氧镁铝可明显抑制应激性胃溃疡、幽门结扎性胃溃疡和利血平性胃溃疡的形成 ,且可促进烧灼性胃溃疡的愈合 ,对胃酸酸度和胃蛋白酶活性有明显的抑制作用。结论 :氢氧镁铝可通过抑制胃酸酸度和胃蛋白酶活性起到抗胃溃疡作用
Objective: To investigate the effect of a new antacid magnesium aluminum hydroxide on experimental gastric ulcer. Methods: The model of stress gastric ulcer in mice, cautery gastric ulcer in mice, reserpine-induced gastric ulcer in rats and gastric ulcer in rat pylorus were used. In the model of pyloric ligation of gastric ulcer, Volume, gastric acidity, p H value of gastric juice and pepsin activity. Results: Magnesium aluminum hydroxide could obviously inhibit the formation of gastric ulcer, pyloric ulcer and reserpine-induced gastric ulcer, and promote the healing of gastric ulcer. The gastric acid acidity and pepsin activity were significantly Inhibition. CONCLUSIONS: Magnesium aluminum hydroxide can inhibit gastric ulcer by inhibiting gastric acidity and pepsin activity