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与牙齿敏感症起始阶段有关的主要神经纤维是A纤维,在A纤维存在或邻近部位中,暴露牙本质对流体动力学刺激产生敏感性。在正常牙中,短时液体流动引起直接和短时的明显疼痛,牙齿敏感症患者则可有疼痛的加重和(或)疼痛时间的延长。A纤维对炎症性介质相对不敏感,而牙髓中C纤维则被许多介质所兴奋。 在炎症前或炎症中,牙本质最内层和邻近牙髓中细胞外液离子成分的变化可增加感觉神经末梢的兴奋性。pH值高于7.4时。兴奋性增加;pH值低于7.4则兴奋性降低。暴露牙本质下方细胞外液中除去Ca~(2+)也可增加神经兴奋性。
The major nerve fibers associated with the initial stage of tooth sensitivity are A fibers, which are sensitized to hydrodynamic stimulation in the presence or vicinity of A fibers by exposure of dentin. In normal teeth, short-term fluid flow causes immediate and short-term significant pain, and tooth-sensitivity sufferers may experience increased pain and / or prolonged pain. A fiber is relatively insensitive to inflammatory mediators, while C fiber in the pulp is much more excited by many media. Changes in extracellular fluid ion composition in the innermost dentin and adjacent pulp can increase the excitability of sensory nerve endings before or during inflammation. pH above 7.4. Excitability increased; pH below 7.4 decreased excitability. Exposure to extracellular fluid below the dentin removes Ca 2+ and increases neuronal excitability.