【摘 要】
:
Peripheral nerve damage,such as that found after surgery or trauma,is a substantial clinical challenge.Much research continues in attempts to improve outcomes after peripheral nerve damage and to promote nerve repair after injury.In recent years,lowintens
【机 构】
:
Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of Califo
论文部分内容阅读
Peripheral nerve damage,such as that found after surgery or trauma,is a substantial clinical challenge.Much research continues in attempts to improve outcomes after peripheral nerve damage and to promote nerve repair after injury.In recent years,lowintensity pulsed ultrasound (LIPUS) has been studied as a potential method of stimulating peripheral nerve regeneration.In this review,the physiology of peripheral nerve regeneration is reviewed,and the experiments employing LIPUS to improve peripheral nerve regeneration are discussed.Application of LIPUS following nerve surgery may promote nerve regeneration and improve functional outcomes through a variety of proposed mechanisms.These include an increase of neurotrophic factors,Schwann cell (SC) activation,cellular signaling activations,and induction of mitosis.We searched PubMed for articles related to these topics in both in vitro and in vivo animal research models.We found numerous studies,suggesting that LIPUS following nerve surgery promotes nerve regeneration and improves functional outcomes.Based on these findings,LIPUS could be a novel and valuable treatment for nerve injury-induced erectile dysfunction.
其他文献
There have been a number of recent developments in the treatment of castration-resistant prostate cancer which seek to exploit the hormonal axis.Still,the castration-resistant prostate cancer remains a major challenge since this is the lethal and incurabl
The Gleason grading system for prostate cancer (PCa) was developed in the 1960s by DF Gleason.Due to changes in PCa detection and treatment,the application of the Gleason grading system has changed considerably in pathology routine practice.Two consensus
Bone metastases have a major impact on quality of life and survival of patients with advanced prostate cancer.In the last decade,the development and approval of substances inhibiting the vicious cycle of bone metastases have enabled the reduction of compl
The International Prostate Forum (IPF)originally started with three urology departments in Japan,Turkey,and the United States.The forum focused on talks and presentations with discussions covering almost all areas of prostatic diseases,including both beni
In this special issue of the Asian Journal of Andrology,speakers of the 12th Genitourinary Reconstructive Surgeons (GURS)-Masterclass in London have written up the topic of their lecture for deeper insights and understanding and to allow a wider audience
We sought to evaluate the ability of fine-needle aspiration (FNA) mapping to find sperm and to guide sperm retrieval after failed microdissection testicular sperm extraction (micro-TESE) in nonobstructive azoospermic men.In this study of consecutive male