【摘 要】
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Objectives The effects of car-vedilol on calcium current (ICa) were investigated in isolated adult rat ventricular myocytes. Methods ICa was recorded by using w
【机 构】
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Division of Clinical Electrophysiology, Guangdong Cardiovascular Institute;Research Center of Medica
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Objectives The effects of car-vedilol on calcium current (ICa) were investigated in isolated adult rat ventricular myocytes. Methods ICa was recorded by using whole-cell patch-clamp recording technique. Results Carvedilol reversibly inhibited ICa in a concentration-dependent manner, carvedilol at 0.1,0.3, 1 and 10 μmol/L in the extracellular solution dec-reased peak ICa by 1.52%, 18.04%, 37.34% and 72.18%,respectively. The steady-state inactivation curve of ICa was shifted to more negative potentials, while the activ-ation curve was not altered. The recovery from inactiva-tion was shifted to right direction, it could not be recovered completely. In addition, Pretreatment of ventricular myocytes with prazosin and propranolol couldn’t block the carvedilol-induced reduction of Ica.Conclusions Carvedilol inhibits ICa in adult rat ventricular myocytes by mechanisms involving preferential interaction with the inactivated state of calcium channel.
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