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目的:探讨左甲状腺素治疗肾病综合征(Nephrotic Syndrome,NS)合并甲状腺功能减退症(Hypothyroidism)的治疗效果。方法:采用放射免疫法测定50例健康体检者及37例NS合并甲减(左甲状腺素组与常规治疗组)治疗前后血清甲状腺功能水平,观察应用左甲状腺素的治疗效果。结果:NS合并甲状腺功能减退者FT3、FT4水平治疗前均明显低于健康体检组(P<0.01),sTSH治疗前后均无明显差异(P>0.05);与治疗前比较,两组治疗后FT3、FT4水平均明显升高(P<0.05);治疗后同期左甲状腺素组FT3、FT4明显高于常规治疗组(P<0.05);左甲状腺素组缓解率明显高于常规治疗组(P<0.05),完全缓解时间短于常规治疗组。结论:NS合并甲减者在常规治疗基础上,给予小剂量左甲状腺素有利于甲状腺功能恢复和尿蛋白转阴,缩短病程,提高缓解率。
Objective: To investigate the therapeutic effect of levothyroxine on Nephrotic Syndrome (NS) with hypothyroidism. Methods: Serum thyroid function was measured by radioimmunoassay in 50 healthy subjects and 37 NS with hypothyroidism (levothyroxine group and conventional treatment group) before and after treatment. The therapeutic effect of levothyroxine was observed. Results: The levels of FT3 and FT4 in patients with NS complicated with hypothyroidism were significantly lower than those in the healthy group (P <0.01) before and after treatment, and there was no significant difference between the two groups before and after treatment (P> 0.05) (P <0.05). After treatment, the levels of FT3 and FT4 in levothyroxine group were significantly higher than those in routine treatment group (P <0.05), and the response rate in levothyroxine group was significantly higher than that in routine treatment group (P < 0.05), complete remission time is shorter than the conventional treatment group. Conclusions: On the basis of routine treatment, administration of low-dose levothyroxine to the patients with NS combined hypothyroidism is beneficial to the recovery of thyroid function and urine protein, shortening the course and improving the remission rate.