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目的 研究Graves眼病患者外周血细胞因子表达及与患病的关系。方法 检测 35例Graves眼病患者急性期行米歇尔方案治疗前和治疗后组及 15例Graves眼病慢性缓解期组患者外周血中白细胞介素 2 (interleukin 2 ,IL 2 )、白细胞介素 6 (interleukin 6 ,IL 6 )、可溶性白细胞介素 2受体(solubleinterleukin 2receptor,sIL 2R)、可溶性白细胞介素 6受体 (solubleinterleukin 6receptor ,sIL 6R)及肿瘤坏死因子 (tumornecosisfacters,TNF)的浓度 ,并将急性期米歇尔方案治疗前与治疗后组患者外周血细胞因子的浓度进行对比。结果 急性期患者治疗前组外周血中的IL 2、sIL 2R、IL 6、sIL 6R及TNF平均浓度分别为 (13 86± 2 0 6 )U/ml、(6 4 2 86± 12 3 90 )U/ml、(10 5 11± 15 77)U/ml、(2 4 38 0 6± 2 18 88)pg/ml及 (49 91± 9 0 8)U/ml,除IL 2外 ,均高于对照组 (P <0 0 1) ;治疗后组外周血中的sIL 2R、sIL 6R及TNF平均水平分别下降至 (437 75± 90 5 4 )U/ml、(2 14 2 31± 30 1 0 8)pg/ml及 (37 6 3± 6 12 )U/ml,接近慢性缓解期患者 ,仍高于对照组。治疗后组、缓解组及对照组外周血中的IL 6平均浓度间差异无显著意义 (P >0 0 5 )。外周血中sIL 2R、IL 6及TNF间呈正相关 (P <0 0 5 )。结论 多?
Objective To study the relationship between the expression of cytokines in peripheral blood and patients with Graves ophthalmopathy. Methods The levels of interleukin 2 (IL 2), interleukin 6 (IL-6) and interleukin-6 (IL-6) in peripheral blood of 35 Graves ophthalmopathy patients before and after treatment with Michel’s regimen and 15 patients with chronic remission of Graves ophthalmopathy interleukin 6, IL 6), soluble interleukin 2 receptor (sIL 2R), soluble interleukin 6 receptor (sIL 6R) and tumor necrosis factor (TNF) The levels of peripheral blood cytokines in patients with acute phase of Michel regimen before and after treatment were compared. Results The average levels of IL-2, sIL 2R, IL-6, sIL 6R and TNF in the peripheral blood of the patients with acute phase were (13 86 ± 2 0 6) U / ml and (6 4286 ± 12 3 90) U / ml, (10 5 11 ± 15 77) U / ml, (24 38 0 6 ± 2 18 88) pg / ml and (49 91 ± 90 8) U / ml, (P <0.01). The average level of sIL 2R, sIL 6R and TNF in the peripheral blood of the treated group decreased to (437 75 ± 90 5 4) U / ml, (2 14 2 31 ± 30 1) 0 8) pg / ml and (37 6 3 ± 6 12) U / ml, which were close to the patients with chronic remission, were still higher than the control group. There was no significant difference in the mean concentration of IL-6 in the peripheral blood between the treatment group, the remission group and the control group (P> 0.05). There was a positive correlation between sIL 2R, IL 6 and TNF in peripheral blood (P <0.05). Conclusion?