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目的 :探讨测定SAC/PRA值对原发性醛固酮增多症的诊断价值。方法 :采用放射免疫分析法测定 4 8例原发性醛固酮增多症患者和 3 0例正常人的血浆肾素 (PRA) ,血管紧张素Ⅱ (AT -Ⅱ )以及血清醛固酮(Aldo) ,并计算醛固酮浓度 /肾素活性 (SAC/PRA)比值。结果 :正常组PRA、AT -Ⅱ、Aldo测定值分别为 0 5 7±0 0 8ng/ml/h ,3 6 0 3± 6 11ng/L ,0 3 3± 0 0 4nmol/L ;原醛患者PRA、AT -Ⅱ、Aldo测定值分别为 0 14± 0 0 8ng/ml/h ,2 1 2 1± 7 5 5ng/L ,1 0 7± 0 3 4nmol/L。与正常对照组比较 ,均有极显著性差异 (p <0 0 0 1)。SAC/PRA(ng/dl/ng·ml-1·h-1) 913± 4 0 9。结论 :合理使用SAC/PRA比值有助于原发性醛固酮增多症的诊断
Objective: To investigate the value of SAC / PRA in the diagnosis of primary aldosteronism. Methods: Radioimmunoassay was used to determine plasma renin (PRA), angiotensin Ⅱ (AT-Ⅱ) and aldosterone (Aldo) in 48 patients with primary aldosteronism and 30 normal controls. Aldosterone concentration / renin activity (SAC / PRA) ratio. Results: The values of PRA, AT-Ⅱ and Aldo in the normal group were 0 57 ± 0 0 8 ng / ml / h, 3 6 0 3 ± 6 1 1 ng / L and 0 3 3 ± 0 0 4 nmol / The measured values of PRA, AT-Ⅱ and Aldo were 0 14 ± 0 0 8 ng / ml / h, 2 1 2 1 ± 7 5 5 ng / L and 1 0 7 ± 0 3 4 nmol / L, respectively. Compared with the normal control group, there was a significant difference (p <0 0 0 1). SAC / PRA (ng / dl / ng · ml-1 · h-1) 913 ± 409. Conclusion: The rational use of SAC / PRA ratio is helpful for the diagnosis of primary aldosteronism