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目的研究瑞士乳杆菌(Lactobacillus helveticus)及其发酵产物对小鼠免疫功能的影响。方法给小鼠灌服乳酸菌样品后,对其免疫功能指标进行测定,主要包括小鼠免疫器官指数(脾脏和胸腺),巨噬细胞吞噬功能,脾淋巴细胞增殖功能,NK细胞活性功能以及血清中IgG的含量。结果瑞士乳杆菌活菌液及其发酵乳清能够显著提高巨噬细胞的吞噬功能,显著的激活B淋巴细胞活性,同时瑞士乳杆菌发酵乳清还可以显著增加血清中IgG的含量。结论瑞士乳杆菌活菌液及其发酵乳清对特异性细胞免疫功能和体液免疫功能以及非特异性免疫功能均有明显的促进作用,能够增强小鼠免疫功能,效果强于其细胞裂解液及普通酸乳。瑞士乳杆菌的免疫活性成分既包括菌体所含细胞壁成分,也包括其代谢产物。
Objective To study the effect of Lactobacillus helveticus and its fermentation products on immune function in mice. Methods Mice were inoculated with lactic acid bacteria samples, and their immune function indexes were determined, including immune organ index (spleen and thymus), macrophage phagocytosis, splenic lymphocyte proliferation, NK cell activity and serum IgG content. Results Live Lactobacillus helveticus and its fermentation whey significantly increased the phagocytosis of macrophages and significantly activated the activity of B lymphocytes. At the same time, Lactobacillus helveticus could significantly increase the IgG content in serum. Conclusions Live Lactobacillus helveticus and its fermented whey significantly promote the specific cellular immunity and humoral and nonspecific immune functions and enhance the immune function of mice with stronger effects than their cell lysates and normal Yogurt. The immunocompetent components of Lactobacillus helveticus include both the cell wall components contained in the cells and their metabolites.