目的:探讨父母亲心理因素对先天性胎儿畸形是否有影响。方法:采用焦虑自评量表(SAS)、抑郁自评量表(SDS)对274例观察组对象及262例对照组对象的心理健康状况进行评分,运用病例对照分析的方法进行结果分析。结果:1柳州市孕妇及其配偶的焦虑和抑郁平均得分、异常率均低于国内其他地区的相关调查结果;2观察组孕妇及配偶的抑郁和焦虑平均得分均低于对照组,且差异有统计学意义(P<0.05);3观察组孕妇SDS和SAS评分异常有3例,异常检出率为1.09%,分别低于对照组的11例和4.20%,且差异有统计学意义(χ2=5.07,P<0.05);观察组的配偶SDS和SAS评分异常有1例,异常检出率为0.36%,分别低于对照组的3例和1.15%,但差异无统计学意义(χ2=0.287,P>0.05)。结论:父母亲心理因素对先天性胎儿畸形的影响具有不确定性,有待进一步探讨。 Objective: To investigate whether psychological factors of parents affect congenital fetal malformations. Methods: The anxiety self-rating scale (SAS) and depression self-rating scale (SDS) were used to score the mental health status of 274 observation groups and 262 control groups. The case-control analysis was used to analyze the results. Results: 1 The average anxiety and depression scores of pregnant women and their spouses in Liuzhou were lower than those in other regions of China. 2 The average scores of depression and anxiety in pregnant women and their spouses in the observation group were lower than those in the control group (P <0.05) .3 In the observation group, there were 3 abnormalities of SDS and SAS in pregnant women, the abnormal detection rate was 1.09%, which were lower than that of the control group (11 and 4.20%, respectively) (χ2 = 5.07, P <0.05). There was 1 case of abnormal SDS and SAS scores in the observation group, the abnormal detection rate was 0.36%, which was lower than 3 cases and 1.15% in the control group respectively, but the difference was not statistically significant (χ2 = 0.287, P> 0.05). Conclusion: The influence of parents psychological factors on congenital fetal malformations is uncertain and needs to be further explored.