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目的探讨分析应用多西他赛联合铂类和培美曲塞联合铂类对非小细胞肺癌患者进行治疗的临床效果。方法 38例非小细胞肺癌患者,采用随机数字法将其分成对照组和研究组,每组19例。对照组患者采用多西他赛联合铂类实施治疗,研究组患者采用培美曲塞联合铂类实施治疗。比较两组治疗效果。结果研究组患者的临床治疗效果与对照组比较,差异无统计学意义(P>0.05)。对两组患者的不良反应发生情况进行分析比较,两组中性粒细胞下降与脱发方面比较差异具有统计学意义(P<0.05);两组贫血、恶心呕吐与血小板下降方面比较差异无统计学意义(P>0.05)。结论应用多西他赛联合铂类和培美曲塞联合铂类对非小细胞肺癌患者进行治疗,其临床治疗效果没有较为明显的差异,但是就毒副作用方面而言,培美曲塞联合铂类更加适合在临床中广泛的推广应用。
Objective To investigate the clinical effect of docetaxel combined with platinum and pemetrexed combined with platinum in the treatment of patients with non-small cell lung cancer. Methods Thirty-eight patients with non-small cell lung cancer were divided into control group and study group by random number method, with 19 cases in each group. Patients in the control group were treated with docetaxel plus platinum, and patients in the study group were treated with pemetrexed plus platinum. Compare the treatment effect of two groups. Results The clinical efficacy of the study group was not significantly different from that of the control group (P> 0.05). Adverse reactions between the two groups were analyzed and compared, two groups of neutrophils decreased and hair loss compared with statistical significance (P <0.05); two groups of anemia, nausea and vomiting and thrombocytopenia were no significant difference Significance (P> 0.05). Conclusion Docetaxel combined with platinum and pemetrexed combined with platinum on the treatment of patients with non-small cell lung cancer, the clinical effect of treatment there is no significant difference, but in terms of toxic side effects, pemetrexed combined with platinum Class is more suitable for wide application in clinical practice.