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人们印象中的伤寒病是一种肠道传染病,故称为“肠伤寒”。近年已有更多的资料显示:确实有脑神经系统的伤寒病存在,简称为“伤寒脑病”。其日益多见及其症状表现的多样化,是近年来伤寒或副伤寒的临床特点之一。 伤寒杆菌通过饮食进入人的消化道,定居在回肠末端的淋巴组织而致病。因此,典型的伤寒病常以消化系统的症状为表现。随之,菌体裂解而释出强烈的内毒素,通过血液、淋巴遍播全身,出现毒血症。当内毒素通过“血脑屏障”而直接侵入脑膜或脑组织,引起相应的神经精神症状,就成为“伤寒脑病”。
Typhoid fever is one of the intestinal infectious diseases, it is called “typhoid fever.” In recent years, more data have shown that there is indeed a presence of typhoid fever in the brain nervous system, referred to as “typhoid fever disease.” It is increasingly seen and the diversification of its symptoms is one of the clinical features of typhoid or paratyphoid in recent years. Salmonella enter the human digestive tract through the diet and colonize the lymphoid tissue at the distal end of the ileum. Therefore, typical typhoid fever often manifests itself as a digestive system. Subsequently, the cell lysate and release a strong endotoxin, through the blood, lymphatic spread throughout the body, there is sepsis. Endotoxin through the “blood-brain barrier” and directly invade the meninges or brain tissue, causing the corresponding neuropsychiatric symptoms, it becomes “typhoid encephalopathy.”