论文部分内容阅读
本文旨在探讨接受长期氧疗(LTOT)的慢性阻塞性肺疾病(COPD)患者吸入一氧化氮(NO)对肺血液动力学及氧合作用的影响。病人和方法.所研究的18(男12、女6)例病人平均年龄57(41～75)岁,均具有COPD证据,能自主呼吸并接受LTOT>15h/d。所有血液动力学及氧合分析用心脏输出计算机及压力监测仪完成,NO经NO装置(Pulmonox)加入并用化学发光分析仪连续分析NO及NO氧化产物浓度。调整吸入氧气部分(FIO_2),将血气调节至与用LTOT时匹配的水平(对照值)。然后在氧/混合气体中分别加入5、10和20ppm的
This article aims to investigate the effects of inhaled nitric oxide (NO) on pulmonary hemodynamics and oxygenation in patients with chronic obstructive pulmonary disease (COPD) receiving long-term oxygen therapy (LTOT). PATIENTS AND METHODS The mean age of the 18 (12 male and 6 female) patients studied was 57 (41-75 years) with COPD evidence of spontaneous breathing and LTOT> 15 h / d. All hemodynamic and oxygenation analyzes were performed using a cardiac output computer and a pressure monitor, NO was added via Pulmonox and the NO and NO oxidation product concentrations were continuously analyzed by a chemiluminescence analyzer. Adjust the fraction of inhaled oxygen (FIO_2) and adjust the blood gas to levels that match those of LTOT (control). Then 5, 10 and 20 ppm were added to the oxygen / mixed gas, respectively