论文部分内容阅读
目的:了解c—kit受体和CD_(34)在急性髓细胞白血病的表达,探讨其与化疗疗效的关系.方法:应用流式细胞仪,测定10例正常人和87例急性髓细胞白血病骨髓c-kit受体和CD34的表达.结果和结论:正常人骨髓c-kit受体和CD34表达率分别为0.5%和1.7%.以>20%细胞表达为阳性,患者c-kit受体和CD34阳性率分别为52%和37%.c-kit受体和CD34阳性病例缓解率较低,差异有显著性(P<0.01),c-kit受体及CD34共同表达者疗效尤差(P<0.05).
OBJECTIVE: To investigate the expression of c-kit receptor and CD_(34) in acute myeloid leukemia and to investigate its relationship with the efficacy of chemotherapy. Methods: Flow cytometry was used to determine the bone marrow of 10 normal individuals and 87 patients with acute myeloid leukemia. Expression of c-kit receptor and CD34. Results and conclusions: The expression rates of c-kit receptor and CD34 in normal human bone marrow were 0.5% and 1.7%, respectively. The expression was positive in >20% cells. The c-kit receptor and The positive rates of CD34 were 52% and 37%, respectively. The response rates of c-kit receptor and CD34 positive cases were lower, the difference was statistically significant (P<0.01), and the co-expression of c-kit receptor and CD34 was particularly poor (P<0.05). <0.05).