论文部分内容阅读
大量实验资料表明,凡生长或分化旺盛的组织(如胚胎细胞、肿瘤等)都有高度的“核酸-蛋白质”的合成过程。而且,细胞分裂旺盛的组织摄取P~(32)增加(薛社普,1964)。因此可以用肿瘤组织核酸含量以及P~(32)摄入速率作为其生长速度的指标。 为了观察长效避孕药炔诺酮庚酸酯(Norethindrone enanthate,简称庚炔诺酮)是否与癌瘤的发生或发展有关系,除去已使用C_(57)纯种小鼠及大鼠长期给药以了解其有无致癌可能外,我们认为还应观察其对肿瘤生长速度与潜伏期的影响。因此,选用了起源于自发乳腺癌的小鼠肉瘤180及大鼠Walker癌作为实验材料,观察了庚炔诺酮及与其配伍应用的长效雌激素对移植性肿瘤和正常组织中核酸含量以及P~(32)参入肿瘤组织核酸速率的影响。
A large number of experimental data show that where the growth or differentiation of tissues (such as embryonic cells, tumors, etc.) have a high degree of “nucleic acid - protein” synthesis process. In addition, the cellular uptake of tissue increased in P32 (Xue et al., 1964). Therefore, we can use the tumor tissue nucleic acid content and P ~ (32) intake rate as an indicator of its growth rate. To observe whether long-acting contraceptive Norethindrone enanthate (Norethindrone enanthate) is associated with the development or progression of carcinomas, chronic administration of C57 (57) purebred mice and rats In order to understand its possible carcinogenic, we think it should also observe the impact of tumor growth rate and latency. Therefore, the selection of spontaneous breast cancer derived from murine sarcoma 180 and rat Walker cancer as experimental material, observation of norethisterone and its compatibility with the application of long-acting estrogen in transplanted tumors and normal tissue nucleic acid content and P ~ (32) into the tumor tissue nucleic acid rate.