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目的:探讨痰瘀同治法对进展期胃癌术后患者血清血管内皮生长因子(VEGF)表达的影响。方法:将符合纳入标准的进展期胃癌患者,随机分为治疗组和对照组各30例。对照组行常规辨证论治,治疗组在常规辨证论治的基础上,结合辨病治疗加入痰瘀同治方。比较两组疗效及患者血清VEGF的变化情况。结果:两组治疗后积分较治疗前均降低,差异均有统计学意义(P<0.05);治疗后KPS评分较治疗前均降低,差异均有统计学意义(P<0.05);治疗组治疗后血清VEGF较治疗前降低,差异有统计学意义(P<0.05);治疗后组间比较,差异有统计学意义(P<0.05)。结论:痰瘀同治法治疗进展期胃癌术后患者,有一定的疗效,能降低患者血清中VEGF表达水平。
Objective: To investigate the effect of Phlegm and Blood Stasis Syndrome on the expression of serum vascular endothelial growth factor (VEGF) in postoperative patients with advanced gastric cancer. Methods: Patients with advanced gastric cancer who met the inclusion criteria were randomly divided into treatment group and control group, with 30 cases each. The control group routine conventional treatment based on syndrome differentiation, the treatment group based on the conventional diagnosis and treatment, combined with disease treatment to join phlegm and blood stasis. The curative effect of two groups and the change of serum VEGF were compared. Results: After treatment, the scores of both groups were significantly lower than those before treatment (P <0.05). The scores of KPS after treatment were lower than those before treatment (P <0.05), and the treatment group After treatment, serum VEGF decreased compared with before treatment, the difference was statistically significant (P <0.05); after treatment, the difference between the two groups was statistically significant (P <0.05). Conclusion: The treatment of phlegm and blood stasis to treat patients with advanced gastric cancer has some curative effect, which can reduce the expression of VEGF in serum.