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对以前患过风湿热的病人,用预防呼吸道A组链球菌感染来防止风湿热复发的这一方法,对于降低风湿性心脏病的发病率及严重性很为重要。每四周肌肉注射长效西林120万u最为有效,但因肌注部位痛感较重,加之有出现过敏反应的危险性,所以,大多数医生改用青霉素口服法。作者以前就发现,口服青霉素(通常20万u),一日二次)只促使链球菌感染者的,48％具有产生抗体反应的能力。
For patients with previous rheumatic fever, the prevention of respiratory group A streptococcal infection to prevent the recurrence of rheumatic fever, this method for reducing the incidence and severity of rheumatic heart disease is very important. Every four weeks long-term intravenous injection of Xilin 1.2 million u most effective, but due to severe pain in intramuscular injection site, coupled with the risk of allergic reactions occur, so most doctors use penicillin oral. The authors have previously found that oral administration of penicillin (usually 200,000 u, twice a day) only contributed to streptococcal infection, 48% have the ability to produce antibody responses.