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目的评价新生儿乙肝重组酵母疫苗普种预防HBV感染的免疫效果,探讨乙肝重组酵母疫苗免疫持久性。方法采用出生队列定群研究结合横断面调查的方法,研究乙肝重组酵母疫苗免疫人群的效果;用固相放射免疫分析法检测HBV感染标志。结果(1)HBsAg平均阳性率1.9%(95%CI 1.4~2.4%),总保护性抗体阳性率为53.2%(95%CI 51.2%~55.2%)。(2)从免疫后1年的88.2%下降到免疫后9年的44.3%。(3)疫苗保护率为89.9%,与2000年的数据比较无显著性差异。结论新生儿普种乙肝疫苗可有效预防HBV感染,免疫人群乙肝保护性抗体水平随接种年限延长呈下降趋势,但疫苗保护效果仍然稳定。
Objective To evaluate the immunogenicity of hepatitis B recombinant yeast vaccine in prevention of HBV infection and to explore the immune persistence of hepatitis B recombinant yeast vaccine. Methods The cohort study of birth cohort and cross-sectional investigation was used to study the effect of recombinant hepatitis B vaccine (HBV) vaccine on the immunization of human beings. HBV infection markers were detected by solid phase radioimmunoassay. Results (1) The average positive rate of HBsAg was 1.9% (95% CI 1.4-2.4%). The positive rate of total protective antibody was 53.2% (95% CI 51.2% -55.2%). (2) decreased from 88.2% at 1 year after immunization to 44.3% at 9 years after immunization. (3) The vaccine protection rate was 89.9%, no significant difference compared with the data in 2000. Conclusions The neonatal hepatitis B vaccine can effectively prevent HBV infection. The level of protective antibody against hepatitis B in immunized population shows a decreasing trend with prolongation of vaccination, but the protective effect of vaccine is still stable.