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目的探讨前列地尔对早期糖尿病肾病患者的临床疗效。方法我院65例早期糖尿病肾病患者给予前列地尔治疗,比较治疗前与治疗14d后ACR、肝功能及血脂改善情况。结果治疗14d后,全组患者ACR、ALT、AST、TC、TG及LDL检测均较治疗前有明显降低,差异有统计学意义(P<0.05),HDL较治疗前升高,差异有统计学意义(P<0.05)。结论前列地尔治疗早期糖尿病肾病患者,可显著改善患者肝、肾脏功能,调节血脂代谢,获得较好的临床效果,对患者的康复有积极的意义。
Objective To investigate the clinical effect of alprostadil on patients with early diabetic nephropathy. Methods 65 patients with early diabetic nephropathy in our hospital were treated with alprostadil. The ACR, liver function and serum lipids were compared before and 14 days after treatment. Results After 14 days of treatment, the levels of ACR, ALT, AST, TC, TG and LDL in all the patients were significantly lower than those before treatment (P <0.05), and the levels of HDL were higher than those before treatment Significance (P <0.05). Conclusion Alprostadil treatment of patients with early diabetic nephropathy can significantly improve liver and kidney function, regulate blood lipid metabolism and achieve better clinical results, which have positive significance for the patients’ recovery.